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Can Acesulfame-K and Aspartame Cause Cancer?

Aspartame and acesulfame-K are popular artificial sweeteners. They are found in various food and beverage products, including diet sodas and sugar-free gum. Many believe these products are a healthier alternative to sugar, but a new studies has linked them to increased cancer risk.

What is Acesulfame-K and Aspartame?

Aspartame is a very common artificial sweetener made up of two amino acids, phenylalanine, and aspartic acid.

Acesulfame-K is another artificial sweetener that is often used in conjunction with aspartame. It is around 200 times sweeter than sugar, making it a popular choice for those looking to cut back on their sugar intake.

The Dangers of Aspartame and Acesulfame-K

A study conducted by researchers at the University of California, San Diego found that rats who were fed high doses of either aspartame or acesulfame-K developed more tumors than those who were not exposed to the sweeteners.

While this study was conducted on rats, the researchers believe that the results could also apply to humans. They advise people to limit their consumption of foods and beverages containing these artificial sweeteners.

Aspartame, is associated with several health problems, like headaches, weight gain, and depression.

In 2016, another study found that aspartame could enhance the breast cancer risk. Although further research is needed to confirm these findings.

If you are concerned about your cancer risk, talk to your doctor. They can help you make healthy choices to lower your risk.

How Does Aspartame Cause Cancer?

Recent studies have found that Aspartame can cause cancer. In our body, proteins are metabolized in the digestive process and then metabolized into amino acids. Aspartame is broken down into phenylalanine and aspartic acid during digestion.

  • Phenylalanine is an essential amino acid, meaning our bodies need it to function properly.
    • Too much phenylalanine can be toxic.
    • High levels of phenylalanine have been linked to schizophrenia and other mental disorders.
  • Aspartic acid is a non-essential amino acid, meaning our bodies can produce it independently.
    • However, too much aspartic acid can be harmful.
    • In large doses, aspartic acid can damage the nervous system.

The cancer-causing properties of aspartame are due to the presence of 13C in the amino acids phenylalanine and aspartic acid.

So how do these chemicals cause cancer? The answer is not entirely clear. They may damage DNA or interfere with cell signaling.

The report: Evidence of Stable Isotope 13C Causing All Cancers, by Reginald B. Little. Dept of Natural Science, Stillman College the author concludes that this is evidence that stable uncommon, nonprimordial isotopes (2D, 13C, 15N, 17O, 25Mg, 33S) cause cancer and 13C directly causes cancer.

How Does Acesulfame-K Cause Cancer?

Acesulfame-K contains the chemical methylene chloride, which is a known carcinogen. It is used as an industrial solvent and has been linked to human cancer.

The precursors of acesulfame-K have structures similar to peptides and oligonucleotides. Degradation of oligonucleotides, which may lead to cancer, may be triggered by interactions between acesulfame-K and other compounds.

Human and bacterial cells are both sensitive to acesulfame-K’s disruptive effects.

In contrast to aspartame, which slows down bacterial E. Coli reproduction, experimental findings demonstrate that acesulfame-K has the opposite effect on the colony of E. Coli. Additionally, E. coli enriches amino acids with stable isotopes of C-13, N-15, and O-17.

Diet soda’s acesulfame-K and aspartame may increase the growth rate of cancer-causing E. Coli in the digestive tract.

When a regular diet soda containing acesulfame-K and aspartame, is combined with carbonates (containing large amount of C-13 and O-17 under pressures), the number of E. Coli in the digestive tract increases and serves as a fermenting reactor for E. Coli to produce the amino acids (which are isotopically enriched), for examples, phenylalanine, leucine, glycine, lysine, aspartic acid, and glutamic acid.

Are There Any Safe Artificial Sweeteners?

The short answer is no. There is no such thing as a safe artificial sweetener. All of the artificial sweeteners currently on the market have been linked to health problems in one way or another.

If you are looking for a safe alternative to sugar, your best bet is to avoid all artificial sweeteners and stick with natural options.

How to avoid Aspartame and Acesulfame-K?

If you’re looking to avoid aspartame and acesulfame-K, you can do a few things.

  • Check food labels for these ingredients, and try to eat naturally sweetened foods.
  • You can also look for products certified by the (American) Diabetes Association or the World Health Organization.
  • As always, talk to your doctor or dietitian if you have any questions or concerns about aspartame and acesulfame-K.


Little, R. B. (2022). Evidence of Stable Isotope 13C Causing All Cancers. European Journal of Applied Physics, 4(4), 37–44. https://doi.org/10.24018/ejphysics.2022.4.4.187

Cong, W.-na, Wang, R., Cai, H., Daimon, C. M., Scheibye-Knudsen, M., Bohr, V. A., Turkin, R., Wood, W. H., Becker, K. G., Moaddel, R., Maudsley, S., & Martin, B. (2013, August 7). Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J MICE. PloS one. Retrieved September 26, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737213/#__ffn_sectitle

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Jansson M;Li YC;Jendeberg L;Anderson S;Montelione GT;Nilsson B; (1996, March). High-level production of uniformly ¹⁵N- and ¹³C-enriched fusion proteins in escherichia coli. Journal of biomolecular NMR. Retrieved September 26, 2022, from https://pubmed.ncbi.nlm.nih.gov/8616269/

Landrigan, P. J., & Straif, K. (2021, April 12). Aspartame and cancer – new evidence for causation – environmental health. BioMed Central. Retrieved September 26, 2022, from https://ehjournal.biomedcentral.com/articles/10.1186/s12940-021-00725-y

Lindseth, G. N., Coolahan, S. E., Petros, T. V., & Lindseth, P. D. (2014, June). Neurobehavioral effects of aspartame consumption. Research in nursing & health. Retrieved September 26, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617129/

Shahriar S;Ahsan T;Khan A;Akhteruzzaman S;Shehreen S;Sajib AA; (2020). Aspartame, acesulfame K and sucralose- influence on the metabolism of escherichia coli. Metabolism open. Retrieved September 26, 2022, from https://pubmed.ncbi.nlm.nih.gov/33336183/

Cooper, G. S., Scott, C. S., & Bale, A. S. (2011, August). Insights from epidemiology into dichloromethane and cancer risk. International journal of environmental research and public health. Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166749/



  1. Reginald B. Little says:

    Hi SORZE4, This is well written article. Nice manifestations of scientific method demonstrating theory of ill effects of artificial sweeteners based on and substantiated by some new data and measurements. Saluting your natural sweetener (JustSweet) derived from natural plant stevia and its many healthy, medicinal properties for humans. Cheers, Reginald B. Little

    • Jan Yttereng says:

      Thank you Reginald!
      We apreciate your and other researchers hard work with this important issue.