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Many people have been tricked into believing that artificial sweeteners with artificial sweeteners, such as sucralose, are the lifeline to prevent diabetes and obesity.

However, the health risks associated with the ingredients in sucralose are extensive and can result in more serious side effects.

When research is now being done on such sweeteners, not only sucralose but also others, several negative effects are emerging.

What is sucralose?

Sucralose is a chlorinated sucrose derivative. This means that it is derived from sugar and contains chlorine. It is a so-called covalent chlorine bond. A molecular bond that can not be broken down in the intestine or in nature. So 65 to 95% of what is consumed passes through the body and pollutes nature. Research has shown that sucralose and other chemical sweeteners can affect life in water and on land.

Sucralose was originally discovered during the development of a new insecticide. It was never meant to be consumed, but it was later introduced as a “natural sugar substitute” for the masses, and people had no idea that things were actually toxic.

Side effects and dangers of sucralose

1. May cause diabetes[1]

A study published in the journal Diabetes Care found that if you use sucralose, the risk of developing diabetes is high. According to the study, daily intake of diet soda was associated with a 36% greater risk of metabolic syndrome and a 67% greater risk of type 2 diabetes.

This means that sucralose is among the unexpected triggers of diabetes. So if you have been wondering about the safety of sucralose for diabetes, the clear answer is to be careful – it actually increases the risk of this serious condition.

In addition to revealing that there was an “increase in maximum plasma glucose concentrations” after ingestion of sucralose, it was discovered that there was a 23% reduction in insulin sensitivity, which inhibits glucose absorption in the cells.

A recent 2020 study published in Cell Metabolism found that intake of sucralose in the presence of a carbohydrate rapidly impaired glucose metabolism and resulted in dysregulation of intestinal brain control of glucose metabolism.

2. Increases the risk of irritable bowel syndrome and Crohn’s disease[1]

Several years ago, researcher Xin Qin, M.D., Ph.D., from New Jersey Medical School, found that ingestion of sucralose causes IBS symptoms, ulcerative colitis, and Crohn’s disease. Dr. Qin made this discovery when he examined the rapid increase in IBS among residents of Alberta, Canada over a 20-period period. In short, it went up 643 %.

This led to Qin conducting his study. What did he find?

Sucralose has a more harmful effect on intestinal bacteria than other artificial sweeteners, such as saccharin, because 65% to 95% of sucralose is excreted unchanged through feces. In 1991, Canada became the first country in the world to approve the use of sucralose as an artificial sweetener. In other words, there was a direct link between the amount of sucralose consumed and the increase in inflammatory bowel disease.

A recent study published in Inflammatory Bowel Diseases indicates that the use of artificial sweeteners such as Splenda doubles the risk of Crohn’s disease and may worsen antimicrobial bowel reactivity in people with Crohn’s and other pro-inflammatory conditions.

Does sucralose cause bloat? It certainly can, since it has been linked to serious pro-inflammatory conditions that affect your digestive system.

Sucralose can increase inflammation and cause IBS symptoms in some cases.

3. Connected to Leaky Gut[1]

Does sucralose affect intestinal bacteria? Essentially, the understanding we now have is that because the body cannot digest sucralose, it travels through the human gastrointestinal tract and damages it while walking. It damages the intestinal wall and can potentially cause a leaky gut.

Several studies have confirmed the harmful effects of sucralose on intestinal health. For example, the Journal of Toxicology and Environmental Health published an animal study from Duke University Medical Center which described that Splenda not only significantly reduces beneficial bacteria in the gut but also increases your fecal pH. It reduces the amount of nutrients you can absorb.

4. May generate toxic (and carcinogenic) compounds by heating[1]

A study published in the Journal of Toxicology and Environmental Health found that cooking at high temperatures with sucralose can generate dangerous chloropropanols, a potentially toxic class of compounds. Although sucralose is often used in baked goods, studies show that the stability of the artificial sweetener decreases as the temperature and pH increase.

Not only does sucralose undergo thermal degradation when heated, but researchers also found that chloropropanols, which are a group of contaminants, including genotoxic, carcinogenic, and tumorigenic compounds, are generated.

The researchers in the study published in Food Chemistry concluded that “caution should be exercised when using sucralose as a sweetener when baking food products containing glycerol or lipids.”

If you are wondering if sucralose can cause cancer, this is something that concerns information, especially because sucralose is often used in baked goods and other foods that are heated. More research is needed for concrete evidence of the carcinogenic effects of sucralose.

(Remark: The use of artificial sweeteners in dietary baked goods is banned by the EU[2])

5. Associated with weight gain[1]

Did you think that using sucralose in coffee would help you lose weight? Well, it turns out that epidemiological studies in humans and laboratory studies in animals both suggest a link between the use of artificial sweeteners and weight gain.

In addition, the use of artificial sweeteners may increase the risk of metabolic syndrome, type 2 diabetes, hypertension, and cardiovascular disease. These studies did not evaluate the effect of sucralose, especially on weight gain, but there are studies that indicate that sucralose does not appear to help with weight loss.

In an 18-month study published in the New England Journal of Medicine, 641 children (477 completed the study) were randomly assigned an eight-ounce box per day with either a calorie-free or sugary drink containing 104 calories.

The sugar-free beverage contained 34 milligrams of sucralose, along with 12 milligrams of acesulfame-K. At the end of the study period, the caloric intake from these drinks was 46,627 calories greater for the children in the sugar-sweetened group than in the sucralose-sweetened group.

However, the total weight gain during the 18-month period was only one kilogram greater for children in the sugar-sweetened group. Researchers can not explain the small difference in weight gain given the significant difference in calorie consumption from beverages.

Another study involving adolescents showed no consistent reduction in weight gain two years after families were provided with artificially sweetened beverages to reduce the consumption of soda sweetened with sugar.

So does sucralose cause weight gain? Well, we know that in many cases it does not help with weight loss, and for people who use it in cooking, baking, and coffee strictly to keep track of calorie counting, this does not seem to be an effective weight-loss method.

There have been reports of side effects of sucralose and products made with Splenda, including headaches and allergic reactions. In addition, recent research indicates that ingestion of sucralose can adversely affect intestinal health and even cause metabolic syndrome.

If you tend to use sucralose because it is a calorie-free alternative and you are trying to lose weight, know that studies show that artificial sweeteners like Splenda do not seem to help with weight loss. Instead, choose natural sweeteners that are lower in calories instead.

6. Artificial sweeteners are an environmental threat[3]

People do not think that something they consume will go straight through the body, but artificial sweeteners are produced, consumed, and released into nature in large quantities. They have been identified as new pollutants.

You can find more information about sucralose on the website draxe.com where most of this information is retrieved.

  1. Dr.Axe – https://draxe.com/nutrition/sucralose/
  2. sorze4.com – https://sorze4.com/en/the-use-of-artificial-sweeteners-in-dietary-baked-goods-is-banned-by-the-eu/ 
  3. Academia.edu – Artificial sweeteners – An ignored environmental threat? https://www.academia.edu/66980549/Artificial_Sweeteners_An_Ignored_Environmental_Threat_

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